Phenytoin: Time to steady state: 2–3 weeks: Sampling time and target range: Pre-dose (not critical): 10–20mg/L: Comment: Metabolised in the liver
During a seizure, a patient may experience changes in consciousness, alterations in sight, smell, and taste, and may experience uncontrolled His peak serum phenytoin level corrected for albumin was 79
1,2 Despite normal levels, phenytoin may interfere with the actions of other drugs, including cyclosporine, oral anticoagulants, oral contraceptives, and
Condition / Indication: Therapeutic Drug Monitoring
Here are examples of when levels should be ordered: ¨ Recent medication initiation
5 and 2
N
B
sample prior to next dose) Sample 3–5 days after starting a maintenance dose or following a dose change When a change in the dosage form or brand is prescribed, careful monitoring of phenytoin serum levels should be carried out
Among those receiving 15–20 mg/kg and 20–55 mg/kg weight-based loading dose, 63 % and 51 % respectively did not Nevertheless, the free fraction most accurately reflects the active component of AEDs, and can be of clinical utility in certain scenarios
(2) Never assume a linear relationship exists between steady state concentrations and the dosage given
PNYF
81 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes
81 may differ
1745-7599
A Med-line search of published literature and a synthesis of 10 years of research was performed
5
2 for patients with renal failure (see